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  • Case of metastatic epithelioid haemangioendothelioma from an unknown primary site associated with membranous nephropathy and hypercoagulable state

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Case Reports: Findings that shed new light on the possible pathogenesis of a disease
Case of metastatic epithelioid haemangioendothelioma from an unknown primary site associated with membranous nephropathy and hypercoagulable state
  1. Valeria Ripa1,
  2. Franz Smith1 and
  3. Jeffrey W Goodman2
  1. 1Surgery, Saint Barnabas Medical Center, Livingston, New Jersey, USA
  2. 2Nephrology, Saint Barnabas Medical Center, Livingston, New Jersey, USA
  1. Correspondence to Dr Valeria Ripa; valeriaripa87{at}gmail.com

Abstract

We report a rare case of metastatic epithelioid haemangioendothelioma from an unknown primary site presenting with axillary lymph node metastases. The patient also had a new-onset membranous glomerulonephritis and thromboembolism, which we postulate were paraneoplastic. The pathogenesis of this rare cancer, the risk of misdiagnosis and membranous glomerulonephritis as a paraneoplastic syndrome are discussed.

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http://dx.doi.org/10.1136/bcr-2021-247253

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    Footnotes

    • Contributors VR and FS designated the case report, wrote the original manuscript and revised the original draft. VR edited the table and created the figures. FS supervised and coordinated all work, solved administrative questions, edited the manuscript, and gave final approval for the manuscript submission. VR, FS and JG approved the final version of the manuscript. JWG provided nephrology knowledge and expertise.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.