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Case Reports: Adverse drug reactions and complications
Atezolizumab-induced autoimmune diabetes mellitus presenting as diabetic ketoacidosis and Takotsubo cardiomyopathy
  1. Sachi Singhal1,
  2. Goonja Patel1,
  3. Rohan Bir Singh2,
  4. Aakash Goyal1,
  5. Karen Avgush1 and
  6. Jean Koka3
  1. 1Department of Internal Medicine, Crozer-Chester Medical Center, Upland, PA, USA
  2. 2Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
  3. 3Department of Hematology/Oncology, Crozer-Chester Medical Center, Upland, PA, USA
  1. Correspondence to Dr Rohan Bir Singh; rohan_singh{at}meei.harvard.edu; Jean Koka, Department of Hematology/Oncology, Crozer-Chester Medical Center, Upland, PA, USA; Jkoka{at}ahopc.com

Abstract

Atezolizumab is a humanised monoclonal IgG1 antibody that is used in treating many solid malignancies. Endocrinopathies are known but a rare adverse event of these immunotherapeutic drugs. Autoimmune diabetes induced by atezolizumab has been rarely reported in the literature. We report the case of a woman in her eighth decade with no known history of diabetes who developed new-onset autoimmune diabetes and Takotsubo cardiomyopathy due to the adverse effects of atezolizumab therapy for hepatocellular carcinoma. We also review the characteristics and outcomes of cases previously reported in the literature.

  • Cardiovascular medicine
  • Diabetes
  • Oncology

http://dx.doi.org/10.1136/bcr-2022-250662

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    Footnotes

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    • Contributors SS: Involved with patient management, conception and design, acquisition of patient information and drafting of the article. GP: Involved with the patient management, conception and design of case report, acquisition of patient information and drafting of the article. RBS: Drafting the article and critical revision of the manuscript. AG: Drafting the article and critical revision of the manuscript. KA: Involved with patient management, conception and design, acquisition of patient information and drafting of the article. JK: Involved with patient management, conception and design, acquisition of patient information, drafting of the article, critical revision of the manuscript and supervision of the effort.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.