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IgG4-positive Hashimoto thyroiditis and its association with IgG4-related sclerosing disease
  1. Aagat Sharma Khatiwada1 and
  2. Natasha Choudhury2
  1. 1Department of Otolaryngology, East Surrey Hospital, Redhill, Surrey, UK
  2. 2Department of Otolaryngology, Surrey and Sussex Healthcare NHS Trust, Redhill, UK
  1. Correspondence to Dr Aagat Sharma Khatiwada; aagat.sharmakhat{at}


A woman in her 50s was referred with suspected thyroid malignancy and underwent total thyroidectomy. Immunohistochemical analysis revealed IgG4-positive Hashimoto’s thyroiditis. IgG4-related thyroid disease is poorly understood, and thought to encompass various entities including IgG4-positive Hashimoto’s thyroiditis, Fibrosing Variant of Hashimoto’s thyroiditis, Reidel’s thyroiditis and Graves’ disease with elevated IgG4 levels. Furthermore, it may be associated with a systemic fibrosing condition called ‘IgG4-related sclerosing disease’. The clinical significance of IgG4-positive thyroid disease, however, remains unclear.

  • Thyroiditis
  • Ear, nose and throat/otolaryngology

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  • Contributors ASK was involved in writing the case report and doing the literature review. NC was involved in the conception of the case report, critical revision of the case report, supervision and final approval of the case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.