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Carcinosarcoma with chondroid differentiation and neuroendocrine carcinoma: unusual triphasic tumour arising from intracholecystic papillary neoplasm of the gall bladder
  1. Smitha Mruthyunjayappa1,
  2. Chirag Rasiklal Patel1,
  3. Sushanth Reddy2 and
  4. Sameer Al Diffalha1
  1. 1Pathology, The University of Alabama at Birmingham Hospital, Birmingham, Alabama, USA
  2. 2Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
  1. Correspondence to Dr Smitha Mruthyunjayappa; smruthyunjayappa{at}


Herein, we report a man in his 70s with gallbladder mass. Microscopically, the tumour demonstrated moderately differentiated adenocarcinoma, sarcoma with focal chondroid differentiation and high-grade neuroendocrine tumour component arising in an intracholecystic papillary neoplasm. The patient did not receive adjuvant chemotherapy in the setting of complete surgical resection. Patient presented with extensive metastasis after 47 months and died 3 months later. Due to the low incidence and poor prognosis of this tumour, it is essential to gather all the individual experience-based information. To our knowledge, this is the first reported case of carcinosarcoma arising from intracholecystic papillary–tubular neoplasm.

  • Gastrointestinal surgery
  • Cancer
  • Cancer intervention

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  • Contributors SM: primary author who wrote the draft. CRP: edited the draft and contributed in diagnosing the cancer. SR: surgeon who took care of the patient. SAD: primary pathologist who diagnosed the case, took pictures and edited the draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.