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Case Reports: Adverse drug reactions and complications
Allergy testing for Cremophor in a patient with cervical cancer with infusion reactions to paclitaxel and docetaxel
  1. Kazuho Nakanishi1,
  2. Shizuka Okazaki2,
  3. Go Ichikawa1 and
  4. Shunji Suzuki3
  1. 1Obstetrics and Gynecology, Nippon Medical School Chiba Hokusoh Hospital, Inzai-shi, Chiba, Japan
  2. 2Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai-shi, Chiba, Japan
  3. 3Obstetrics and Gynecology, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, Japan
  1. Correspondence to Dr Kazuho Nakanishi; knakanishi{at}nms.ac.jp

Abstract

A woman in her 30s with cervical cancer underwent postoperative chemotherapy and showed allergic reactions to multiple taxanes. As the patient had infusion reactions to both paclitaxel and docetaxel, a prick test with Cremophor was conducted. In the absence of an allergic reaction to etoposide, we determined that the patient was allergic to pure taxane compounds. Among infusion reactions caused by taxanes, Cremophor allergy is reported in 3% of cases. Therefore, a prick test with Cremophor performed on a taxane infusion reaction will be useful in diagnosing allergy. In addition, allergy due to docetaxel may be managed by adequate premedication and continuous intravenous chlorpheniramine administration.

  • Obstetrics, gynaecology and fertility
  • Cervical cancer
  • Chemotherapy
  • Gynecological cancer
  • Unwanted effects / adverse reactions

https://doi.org/10.1136/bcr-2022-250960

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    Footnotes

    • Contributors KN: conducted the study and wrote the manuscript. SO, GI and SS: critically examined the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.