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Monoclonal gammopathy of undetermined significance causing large vessel vasculitis
  1. Edward George Alcorn,
  2. Lauren Floyd and
  3. Ajay Dhaygude
  1. Department of Nephrology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, Lancashire, UK
  1. Correspondence to Dr Edward George Alcorn; ed.alcorn260{at}


A man in his late 50s presented with unilateral pain and discolouration of his fourth and fifth toes suggestive of digital ischaemia. He had a medical history of two unprovoked venous thromboembolisms in the preceding 18 months and a history of monoclonal gammopathy of undetermined significance (MGUS). A CT scan showed evidence of large vessels vasculitis in the absence of circulating antineutrophil cytoplasmic antibodies. Biopsy of the toes showed evidence of light chain and immunoglobulin deposition on immunofluorescence suggesting vasculitis secondary to his haematological diagnosis of MGUS. The patient was treated with high dose glucocorticoids and immunosuppressive treatment with a significant improvement in his symptoms and features of digital ischaemia.

  • Malignant and Benign haematology
  • Vasculitis
  • Haematology (incl blood transfusion)

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  • Contributors EGA: submitting and corresponding author. Wrote up the case report. LF: edited the case report. Liaised with patient by obtaining consent for the case report and also obtained consent for associated images to be used. AD: main consultant involved in the diagnosis and treatment of the patient. Guided the initial planning of the case report and discussion points.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.