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IgA vasculitis with severe renal manifestation
  1. Joana Marques Dias,
  2. Marta Azevedo Ferreira,
  3. Ana Grilo and
  4. Fernando Martos Gonçalves
  1. Internal Medicine, Hospital Beatriz Angelo, Loures, Lisboa, Portugal
  1. Correspondence to Joana Marques Dias; joana.marques.dias92{at}


IgA vasculitis is a rare systemic vasculitis in adults, frequently more severe than in paediatric age. It manifests with cutaneous, articular, gastrointestinal and renal involvement.

We present a case of a man in his 40s diagnosed with IgA vasculitis with cutaneous, joint, gastrointestinal and renal disease. Significant proteinuria and renal biopsy findings demonstrating crescentic glomerulonephritis led to the onset of early immunosuppression with corticoid and cyclophosphamide. This case report reflects a case of more severe renal impairment due to IgA vasculitis with good outcome with the chosen therapy. The findings in the renal biopsy after treatment supported the good response to the chosen immunosuppression.

  • Vasculitis
  • Immunology
  • Proteinurea

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  • Contributors The department of internal medicine was responsible for the diagnosis and treatment during the hospital stay: AG, JMD, FMG. The nephrology department of Hospital Beatriz Ângelo always collaborated on diagnosis (including renal biopsy). The follow-up was assured by the internal medicine: AG, MAF; and the nephrology department.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.