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Autoimmune storm following alemtuzumab
  1. Chelsea Chan1,
  2. Philippe Beauchemin2,3,
  3. Ana-Luiza Sayao4 and
  4. Mollie Carruthers5
  1. 1Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
  2. 2Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada
  3. 3Neurologie, Faculte de medecine - Universite Laval, Quebec City, Quebec, Canada
  4. 4Division of Neurology, Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
  5. 5Rheumatology, Arthritis Research Canada, Vancouver, British Columbia, Canada
  1. Correspondence to Dr Mollie Carruthers; drmolliecarruthers{at}gmail.com

Abstract

Alemtuzumab has been associated with the emergence of secondary autoimmune diseases. We report a case of a patient with relapsing–remitting multiple sclerosis who developed a refractory immune thrombocytopaenia associated with vasculitis, myelofibrosis and later Guillain-Barré syndrome following alemtuzumab. The medical community should be aware of unusual and unexpected adverse events that may be associated with alemtuzumab, especially when occurring simultaneously in the same patient.

  • Neurology (drugs and medicines)
  • Multiple sclerosis
  • Biological agents
  • Vasculitis

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Footnotes

  • Contributors CC and PB were involved in drafting and revision of the report. MC and A-LS were involved in the revision and final approval of the version to be published.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.