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Primary Burkitt lymphoma of the thyroid associated with Hashimoto’s thyroiditis
  1. Patrick Bergsma1,2,
  2. Cosima Riemenschnitter1,3,
  3. Ulrike Gruber-Mösenbacher4 and
  4. Yves Brand1,5
  1. 1Department of Otolaryngology, Head and Neck Surgery, Cantonal Hospital Graubunden, Chur, Switzerland
  2. 2Department of Otolaryngology, Head and Neck Surgery, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
  3. 3Department of Otolaryngology, Head and Neck Surgery, University Hospital Zurich, Zurich, Switzerland
  4. 4Department of Pathology, Cantonal Hospital Graubunden, Chur, Switzerland
  5. 5Faculty of Medicine, University Basel, Basel, Switzerland
  1. Correspondence to Dr Patrick Bergsma; patrick.bergsma{at}hotmail.com

Abstract

Primary Burkitt lymphoma of the thyroid is an extremely rare entity with only a few reported cases. A female patient in her 70s with Hashimoto’s thyroiditis presented with a 2-month history of progressive left-sided neck swelling. Ultrasound examination revealed a multinodular goitre and fine needle aspiration (FNA) showed no signs of malignancy. The rapid growth of the thyroid mass raised the concern of a lymphoproliferative process. After left thyroid lobectomy and histopathological examination, the diagnosis of Burkitt lymphoma was made and the patient was included in a randomised study providing chemotherapy following a dose adjusted EPOCH-R regimen. Clinical remission was reached after 6 cycles of chemotherapy. There were no signs of relapse on follow-up, 1.5 years after the end of the treatment. Fast growing thyroid nodules in HT warrant a high index of suspicion. Despite no signs of malignancy after FNA cytology, these nodules may need further investigations.

  • Thyroid disease
  • Oncology
  • Ear, nose and throat/otolaryngology

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Footnotes

  • Contributors YB was the main treating physician and initiated the study. PB and CR drafted the manuscript. UG described the pathological findings.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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