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Case Reports: Unusual presentation of more common disease/injury
Therapy-resistant dermatomyositis with extensive ‘lumbar belt’ calcinosis
  1. Juan Manuel Linan-Barroso1,
  2. Alexei Gonzalez-Estrada2 and
  3. Jose Salvador García-Morillo3
  1. 1Dermatology, Hospital Universitario Virgen del Rocio, Seville, Spain
  2. 2Division of Pulmonary, Allergy and Sleep Medicine, Department of Medicine, Mayo Clinic, Jacksonville, Florida, USA
  3. 3Systemic Autoimmune and Rares Diseases Unit. Internal Medicine Department, Hospital Virgen del Rocio, Seville, Spain
  1. Correspondence to Dr Alexei Gonzalez-Estrada; gonzalez.alexei{at}mayo.edu

Abstract

Calcinosis cutis (CC) is the umbrella term for calcium salt deposition on skin and subcutaneous tissue. We present a unique case of CC associated with anti-Mi2-positive dermatomyositis, having a distinctive distribution of subcutaneous calcifications appearing as a ‘lumbar belt’. Treatment of CC remains challenging for clinicians due to a lack of high-quality evidence. Corticosteroids, methotrexate, bisphosphonates, intravenous immunoglobulin replacement, rituximab and sodium thiosulfate failed to halt calcinosis progression in this case. Newer therapies, such as Janus kinase inhibitors, should be considered.

  • Musculoskeletal syndromes
  • Radiology
  • Biological agents
  • Rheumatology

http://dx.doi.org/10.1136/bcr-2022-249110

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    Footnotes

    • Twitter @LinanBarroso, @UCAMIraras

    • Contributors JML-B obtained information from the patient and drafted the initial manuscript. All authors (JML-B, AG-E and JSG-M) reviewed, edited and approved the final version of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.