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Synchronous Hürthle cell and medullary thyroid carcinomas
  1. Zhu Hui Yeap1,
  2. Sam Arman1,
  3. Grant Stenhouse2 and
  4. Aidah Isa1
  1. 1Otolaryngology, NHS Highland, Inverness, UK
  2. 2Pathology, NHS Highland, Inverness, UK
  1. Correspondence to Dr Zhu Hui Yeap; zhuhui.yeap{at}


Hürthle cell carcinoma (HCC) and medullary thyroid carcinomas (MTC) are uncommon histological subtypes of thyroid cancers, each accounting for around 3% of all thyroid cancers. A septuagenarian woman with a history of multiple primary cancer diagnoses presented with a growing left-sided neck lump. A diagnostic left thyroid lobectomy was performed, and pathological examination found two separate malignant foci: one HCC and an MTC. The patient developed left-sided HCC nodal metastasis, and following several multidisciplinary team discussions, a right completion lobectomy with left lateral neck dissection was performed, revealing further intrathyroidal MTC and extranodal extension of HCC. We present this as the first reported case of a collision tumour of HCC and MTC, and review the available literature regarding collision tumours and their management.

  • Ear, nose and throat/otolaryngology
  • Endocrine cancer
  • Head and neck cancer
  • Pathology
  • Otolaryngology / ENT

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  • Contributors All authors were involved in the care and management of the patient. ZHY revised the available literature, drafted and edited the manuscript. GS was responsible for providing images and analysis of histopathological results. SA and AI contributed to supervision, editing and critical revision of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.