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Coexistence of pan-hypogammaglobulinaemia and primary ciliary dyskinesia
  1. Swasthi S Kumar1,
  2. Animesh Ray1,
  3. Sushil Kumar Kabra2 and
  4. Sanjeev Sinha1
  1. 1Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
  2. 2Department of Medicine, Pediatrics, All India Institute of Medical Sciences, New Delhi, Delhi, India
  1. Correspondence to Dr Animesh Ray; doctoranimeshray{at}


A patient, an adolescent male, presented to us with complaints of recurrent respiratory tract infections since childhood. Differentials considered were cystic fibrosis (CF), bronchial asthma with allergic bronchopulmonary aspergillosis (ABPA), primary ciliary dyskinesia (PCD) and primary immunodeficiency disorders. Sweat chloride test, total IgE and Aspergillus fumigatus specific serum IgE and IgG levels were normal ruling out CF and ABPA. Nasal nitric oxide (NO) screening test showed reduced NO levels, and high-speed video microscopy of nasal scrapings showed stiff beating cilia with reduced ciliary beat frequency confirming the diagnosis of PCD. Immunodeficiency workup showed reduced serum IgG, IgA and IgM, when repeated on two separate occasions when the patient was not harbouring any active infection, suggestive of pan-hypogammaglobulinaemia. Thus, a diagnosis of coexistent PCD and pan-hypogammaglobulinaemia was made. Detection of immunodeficiency disorders is important in patients with PCD as they may benefit from immunoglobulin replacement.

  • Immunology
  • Infectious diseases
  • Pneumonia (infectious disease)
  • TB and other respiratory infections

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  • Contributors All the authors were involved in patient diagnosis and management. The initial manuscript was drafted by SSK and AR. The manuscript was revised by SS and SKK and approved for final submission by all authors.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.