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Rare presentation of enoxaparin-induced skin necrosis in a postoperative patient


Enoxaparin-induced skin necrosis is a rare complication of low-molecular weight heparin (LMWH) therapy. We describe a woman in her 50s who developed deep vein thrombosis (DVT), thrombocytopenia and necrotic skin lesions after initiation of enoxaparin for DVT prophylaxis. Despite high clinical suspicion of heparin-induced thrombocytopenia syndrome and a positive heparin–platelet factor 4 antibody, heparin serotonin assay was negative. This case emphasises the importance for clinical vigilance regarding complications to LMWH therapy.

  • Drugs and medicines
  • Drug therapy related to surgery
  • Haematology (drugs and medicines)
  • Skin
  • Haematology (incl blood transfusion)

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