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Case Reports: Rare disease
Severe multisystem inflammatory syndrome in a vaccinated adult with COVID-19
  1. Vijairam Selvaraj,
  2. Arkadiy Finn,
  3. Michael Santos and
  4. Kwame Dapaah-Afriyie
  1. Division of Hospital Medicine, Department of Medicine, Warren Alpert Medical School at Brown University, Providence, Rhode Island, USA
  1. Correspondence to Dr Vijairam Selvaraj; vijairam.selvaraj{at}lifespan.org

Abstract

The ability of SARS-CoV-2 to trigger hyperinflammatory response in children and adults is increasingly recognised. However, the detailed features that distinguish severe COVID-19-associated hyperinflammation from multisystem inflammatory syndrome in adults (MIS-A) is not yet known. We describe a young, vaccinated patient with no prior SARS-CoV-2 exposure who developed COVID-19 and MIS-A. We also provide a review of the current literature on MIS-A and COVID-19-associated hyperinflammation.

  • Infectious diseases
  • Immunology
  • Medical education
  • Medical management
  • Intensive care

https://doi.org/10.1136/bcr-2022-249425

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    Footnotes

    • Twitter @Vj235

    • Contributors VS was involved in obtaining consent and drafting the original document. AF revised the manuscript, did literature review and discussion. MS was involved in direct care of the patient, revised manuscript and edited tables and case presentation. KD-A supervised, reviewed and edited the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.