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Dental management of a patient with systemic mastocytosis
  1. Alexander Richard Legge1,
  2. Andrew Whyte2 and
  3. Simon Heywood1
  1. 1Community Dental Service, University Hospitals Plymouth NHS Trust, Plymouth, UK
  2. 2Department of Allergy and Immunology, University Hospitals Plymouth NHS Trust, Plymouth, UK
  1. Correspondence to Dr Alexander Richard Legge; alexander.legge{at}


Mastocytosis is a term encompassing a group of clinical disorders characterised by clonal proliferation of abnormal mast cells (MCs) in organ systems of the body. Mastocytosis can be systemic (with or without skin involvement) or cutaneous, and can affect organs including bone marrow, liver, spleen, lymph nodes and mucosal surfaces. Patients with systemic mastocytosis (SM) are susceptible to triggers that could cause activation of abnormal MCs, resulting in multiorgan dysfunction and life-threatening anaphylactic reactions. Mastocytosis has a number of ramifications for the dental management of a patient with the condition. Patients are at increased risk of complications due to a number of risk factors for MC activation present within the dental context, including stress, certain prescribed drugs, oral hygiene products and dental materials. This report presents the oral management of an adult with SM, discussing the implications of the condition within the context of the limited existing literature on the subject.

  • Dentistry and oral medicine
  • Immunology
  • Surgery
  • Sedation

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  • Contributors The patient was under the care of ARL, SH and AW. Report was written by ARL and AW.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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