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Polymicrobial bacteraemia with Clostridioides difficile and Pseudomonas aeruginosa in an elderly man following antibiotic use
  1. David T Zhang1,
  2. Catherine W Cai1,
  3. David G Thomas1 and
  4. Joshua Rosenblatt2
  1. 1Department of Medicine, Weill Cornell Medicine, New York, NY, USA
  2. 2Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
  1. Correspondence to Dr David T Zhang; davidtz123{at}


Clostridioides difficile is a micro-organism well known to cause pseudomembranous colitis with rare extraintestinal manifestations. We present the case of an elderly male with multiple comorbidities who presented with acute onset of fever/chills and hypotension, found to have polymicrobial bacteraemia with C. difficile and Pseudomonas aeruginosa. He was treated with piperacillin/tazobactam for P. aeruginosa bacteraemia, oral vancomycin for C. difficile colitis and intravenous, followed by oral metronidazole for C. difficile bacteraemia. Pseudomonas cleared after 1 day, and Clostridioides cleared after 4 days. Following an initial septic presentation, he responded appropriately to antimicrobial therapy and did well in follow-up.

  • Infections
  • Drugs: infectious diseases

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  • Contributors DZ: planning/conception, writing, editing; CC: planning/conception, writing, editing; DT: planning/conception, writing, editing; JR: planning/conception, writing, editing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.