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Chronic inflammation and calciphylaxis
  1. Aaron Byers,
  2. Nicholas Herrera and
  3. Itunu Owoyemi
  1. Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA
  1. Correspondence to Dr Itunu Owoyemi; iowoyemi{at}kumc.edu

Abstract

Calciphylaxis also known as calcific uraemic arteriolopathy is a rare condition mostly seen in patients with end-stage kidney disease. We report a case of a simultaneous-kidney-pancreas transplant patient with functioning grafts developing biopsy-proven calciphylaxis in the setting of chronic inflammation. Despite several modalities of management, the patient developed progression of her disease leading to multiple amputations. This case illustrates chronic inflammation driven by persistent infection as a probable contributing factor to the development and progression of calciphylaxis in a simultaneous kidney-pancreas recipient. Calciphylaxis should be considered in the differential for a painful, non-healing ulcer even in the absence of common risk factors.

  • Renal transplantation
  • Immunology

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Footnotes

  • Twitter @itunuowoyemi

  • Contributors AB: curation and writing the original draft. NH: case report design and manuscript editing. IO: case report design, supervision and writing of the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.