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Chronic demyelinating polyneuropathy preceding T-cell lymphoma: differentiation between primary neurolymphomatosis and paraneoplastic neuropathy
  1. Sooyoung Kim1,
  2. Myoung-Won Lee2,
  3. Song-Yi Choi3 and
  4. Eun Hee Sohn1
  1. 1Department of Neurology, Chungnam National University Hospital, Daejeon, Republic of Korea
  2. 2Department of Hematology, Chungnam National University Hospital, Daejeon, Republic of Korea
  3. 3Department of Pathology, Chungnam National University Hospital, Daejeon, Republic of Korea
  1. Correspondence to Dr Eun Hee Sohn; seh337{at}


A 49-year-old man presented with progressive asymmetric weakness and pain. Electrodiagnostic tests and nerve biopsy suggested chronic demyelinating polyneuropathy refractory to immune-modulating therapy. The patient’s symptoms were aggravated, and he was finally diagnosed with T-cell lymphoma based on the findings of the second 18F-2 fluoro-2-deoxy-glucose positron emission tomography/CT performed 16 months after symptom onset. The patient received intravenous chemotherapy, but died 2 months later because of lymphoma progression. A clinical suspicion of neurolymphomatosis and early diagnosis are important for proper management.

  • neuromuscular disease
  • neurooncology
  • peripheral nerve disease

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  • Contributors SK wrote the manuscript; M-WL provided advice on the patient’s medical condition and contributed to conceiving the case report; S-YC performed and interpreted the pathological examination; EHS contributed to conceiving and designing the case report and critically revising the manuscript. All authors have read and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.