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Case Reports: Rare disease
Invasive stage III breast implant-associated anaplastic large cell lymphoma successfully treated with incomplete resection
  1. John A Nestler1,
  2. Jin Kyung Kim1,
  3. Adam M Goodreau2,
  4. Paschalia M Mountziaris2 and
  5. Kandace P McGuire3,4
  1. 1Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA
  2. 2Department of Plastic and Reconstructive Surgery, Virginia Commonwealth University Health System, Richmond, Virginia, USA
  3. 3Department of Surgery, Virginia Commonwealth University Health System, Richmond, Virginia, USA
  4. 4Massey Cancer Center, Virginia Commonwealth University Health System, Richmond, Virginia, USA
  1. Correspondence to Mr John A Nestler; nestlerja{at}vcu.edu

Abstract

A woman with history of bilateral breast augmentation 15 years prior presented with right breast swelling, peri-implant effusion and a palpable inferomedial mass. Effusion aspiration demonstrated pleiomorphic cells consistent with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). Further diagnostic studies confirmed stage III disease with a 4.7 cm right breast mass and fluorodeoxyglucose uptake in an internal mammary chain lymph node. The patient underwent surgery with incomplete resection due to invasion of the chest wall followed by chemotherapy and radiation therapy. BIA-ALCL typically presents as an indolent effusion, however advanced disease carries a worse prognosis. This case highlights successful treatment without recurrence past the one-year mark as well as the need for multidisciplinary management when dealing with advanced disease.

  • Oncology
  • Breast cancer
  • Chemotherapy
  • Breast surgery
  • Plastic and reconstructive surgery

http://dx.doi.org/10.1136/bcr-2021-246664

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    Footnotes

    • Contributors JAN: drafting and revision of the manuscript for content, including medical writing for content; obtaining consent; major role inthe acquisition of information. JKK: drafting and revision of the manuscript for content, including medical writing for content. AMG: drafting and revision of the manuscript for content, including medical writing for content. PMM: drafting and revision of the manuscript for content, including medical writing for content; media acquisition. KPM: drafting and revision of the manuscript for content, including medical writing for content.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.