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Case Reports: Learning from unexpected outcome (positive or negative)
Primary squamous cell carcinoma of the testis: a rare presentation
  1. Aqsa Zahoor1,
  2. Rajiv Swamy2,
  3. Andrew Gogbashian3 and
  4. Anand Sharma4
  1. 1Medicine, Lister Hospital, Stevenage, UK
  2. 2Histopathology, Lister Hospital, Stevenage, Hertfordshire, UK
  3. 3Consultant Radiologist, Paul Strickland Scanner Centre, Northwood, UK
  4. 4Medical Oncology, Mount Vernon Cancer Centre, Northwood, UK
  1. Correspondence to Dr Anand Sharma; anand.sharma3{at}nhs.net

Abstract

A man in his mid-70s presented with a lump in his left testicle. He had previously been treated for prostate cancer with radical radiotherapy. He was on treatment for hypertension and type 2 diabetes. An ultrasound of the testes demonstrated a solid intratesticular mass for which he underwent left orchidectomy. Histology from the orchidectomy was moderately differentiated squamous cell carcinoma (SCC), positive for cytokeratin (CK) 5/6 and p63. A positron emission tomogram (PET) scan was clear of any metastatic disease. His surveillance CT, done at 12 months, revealed mediastinal, abdominal and hilar adenopathy. Biopsy of hilar lymph nodes showed SCC and this was treated with platinum-based chemotherapy. Unfortunately, the patient died after 18 months. To our knowledge, this is the first reported case of metastatic SCC of testes with extensive spread and with platinum-refractory disease.

  • Prostate Cancer
  • Urological cancer

https://doi.org/10.1136/bcr-2021-246341

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    Footnotes

    • Twitter @drandy2003

    • Contributors AS, AZ have contributed to the write up, editing, AG contributed with radiology and editing, and RS contributed with the histopathology.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.