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Amelanotic melanoma of the palate: report of a case
  1. Swagatika Panda1,
  2. Satya Ranjan Misra2,
  3. Sreepreeti Champatyray1 and
  4. Neeta Mohanty1
  1. 1Oral and Maxillofacial Pathology & Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan deemed to be University, Bhubaneswar, Odisha, India
  2. 2Oral Medicine & Radiology, Institute of Dental Sciences, Siksha 'O' Ansuandhan deemed to be University, Bhubaneswar, India
  1. Correspondence to Professor Neeta Mohanty; neetamohanty{at}


Primary amelanotic melanoma is an infrequent occurrence in the oral cavity. Owing to the high rate of local invasion and distant metastasis, oral amelanotic melanoma (OAM) carries a very poor prognosis. The absence of pathognomonic clinical and routine histological features in OAM is the reason for diagnosticdelay, which further worsens the prognosis. This case report discusses the masquerading nature of OAM that was clinically and histologically mimicking several malignant neoplasms. This case also demonstrates the poor prognosis of OAM. The objective of presenting this case is that the diagnostic delay of OAM can be avoided through enhanced clinical awareness and subsequent appropriate immunohistochemical investigations, in addition to the routine H&E-stained histopathological evaluation.

  • dentistry and oral medicine
  • pathology

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  • Contributors SRM examined the patient. NM and SC performed the investigations. SP prepared the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.