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(Ig)Easy diagnosis of disseminated coccidioidomycosis
  1. Ahad Azeem1,
  2. David Quimby1,
  3. Bryan Krajicek2 and
  4. John Horne1
  1. 1Infectious Diseases, Creighton University, Omaha, Nebraska, USA
  2. 2Pulmonary, Critical Care and Sleep Medicine Department, Creighton University, Omaha, Nebraska, USA
  1. Correspondence to Dr John Horne; johnhorne{at}creighton.edu

Abstract

An immunocompetent man in his 20s came to the hospital for shortness of breath, fevers and lower back pain with unintentional 20 lbs. weight loss. Relevant history included a recent trip to Arizona 3 months prior to presentation. On arrival, he was noted to have decreased breath sounds bilaterally, and paraspinal tenderness in the lumbar area. CT scan revealed diffuse pneumonitis and an abscess with osteomyelitis in the sacrum and right iliac bone. Continued respiratory decompensation led him to the intensive care unit where he had a bronchoscopy and later sacroiliac joint fluid collection was performed. Based on his travel history, and elevated serum IgE, liposomal amphotericin B was initiated. Later his antibodies against Coccidiodes resulted elevated and fungal cultures from the bronchoalveolar lavage and abscess from the sacral vertebrae grew mould, morphologically consistent with Coccidiodes posadasii. He was transitioned to oral fluconazole and will have a close follow-up outpatient.

  • mechanical ventilation
  • infections
  • bone and joint infections
  • pneumonia (infectious disease)
  • adult intensive care

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Footnotes

  • Contributors AA wrote the manuscript with input from other authors. DQ helped in getting cultures slides and radiology images. BK supervised the project. JH contributed to the final version and helped in obtaining the consent form.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

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  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.