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Multifocal hepatic small vessel neoplasm with spleen dissemination
  1. Carlo Maria Cicala1,
  2. Federico Monaca1,
  3. Maria Cristina Giustiniani2 and
  4. Mariantonietta Di Salvatore1
  1. 1Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy
  2. 2Pathology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy
  1. Correspondence to Carlo Maria Cicala; carlom.cicala{at}


Among liver vascular tumours, hepatic small vessel neoplasm (HSVN) has been recently identified as a rare infiltrative vascular neoplasm whose malignant potential is yet to be fully ascertained. About 30 cases of HSVN have been described so far. The most common clinical presentation is an asymptomatic solitary liver lesion. Multifocal disease has been described in literature; however, to date, there are no reports of disease dissemination to other organs. Here we report a case of multifocal HSVN with synchronous spleen secondary lesions.

  • Hepatic cancer
  • Radiology
  • Pathology

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  • Contributors Conceptualisation and investigation: CMC. Data curation and metholodogy: CMC, FM and MCG. Writing: CMC and FM. Supervision: MDS. All authors acquired data, revised and approved the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.