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A Low rectal GIST
  1. Tara M Connelly1,
  2. Cillian Clancy1,
  3. Shaomin Hu2,
  4. Scott R Steele1 and
  5. Hermann Kessler1
  1. 1Colorectal Surgery, Cleveland Clinic Main Campus Hospital, Cleveland, Ohio, USA
  2. 2Department of GI/Liver Pathology, Cleveland Clinic Main Campus Hospital, Cleveland, Ohio, USA
  1. Correspondence to Ms Tara M Connelly; tara_conn{at}


A man in his 70s presented with narrowing of his stool calibre and a palpable mass on rectal examination. Colonoscopy revealed a submucosal bulge without a mucosal lesion. CT and MRI demonstrated an 8×5.4×7 cm mass in lower rectum. Biopsy of the mass confirmed a rectal gastrointestinal stromal tumour (GIST). It was moderately sensitive to neoadjuvant imatinib and radiotherapy, which slightly downsized the tumour. He required abdominal perineal resection with curative intent. Uncommonly found in the rectum, when located here, GISTs are typically aggressive and are a rare cause of stool calibre narrowing. Rectal GISTs should be considered in patients presenting with this symptom.

  • radiology (diagnostics)
  • gastrointestinal system
  • malignant disease and immunosuppression
  • gastrointestinal surgery

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  • Contributors TC: concept, data extraction, writing. CC: data extraction, manuscript writing. SRS Steele-concept, manuscript editing. HK: concept, manuscript writing and editing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.