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Transient neonatal hypocalcaemia caused by maternal hyperparathyroidism
  1. Joana S Gonçalves,
  2. Luisa Carrington Queiró,
  3. Joana Soares and
  4. Cátia R Correia
  1. Pediatrics Department, Centro Hospitalar de Lisboa Ocidental EPE, Lisboa, Portugal
  1. Correspondence to Dr Joana S Gonçalves; joanarsgoncalves{at}gmail.com

Abstract

Hypocalcaemia in neonates can range from asymptomatic to a potentially life-threatening condition. We present a case of a 36 weeks gestational age boy, admitted to our neonatal intensive care unit for jitteriness, mild hypotonia and breastfeeding difficulties. By the ninth day of life, he presented with late-onset hypocalcaemia, hypomagnesaemia, low 25-OH-vitamin D and inappropriately normal parathyroid hormone. Further investigation revealed maternal hypercalcaemia with high parathyroid hormone. Maternal asymptomatic hyperparathyroidism was diagnosed and admitted as the cause of neonatal hypocalcaemia. There was a clinical improvement and calcium levels stabilisation after treatment with calcium gluconate and vitamin D3. This case highlights the importance of careful evaluation of neonatal late-onset hypocalcaemia in uncovering asymptomatic maternal hyperparathyroidism.

  • calcium and bone
  • neonatal intensive care
  • materno-fetal medicine
  • neonatal health

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Footnotes

  • Contributors JG formulated the manuscript’s conception and is the main writer of the case and discussion. LQ, JS and CC contributed to writing and critical revision of the article. Finally, all authors helped on the patient’s diagnosis and treatment.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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