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Anaplastic large cell lymphoma, ALK-negative of the breast diagnosed a short time after removal of breast implant in a patient with breast carcinoma: diagnostic and therapeutic considerations
  1. Margit Riis1,
  2. György Csanaky2,
  3. Gustav Lehne3 and
  4. Aase Tangerud4
  1. 1Department of Breast and Endocrine Surgery, Oslo University Hospital, Oslo, Norway
  2. 2Department of Pathology, Oslo University Hospital, Oslo, Norway
  3. 3Department of Cancer Treatment, Oslo University Hospital, Oslo, Norway
  4. 4Department of Radiology, Oslo University Hospital, Oslo, Norway
  1. Correspondence to Dr Margit Riis; margit.l.riis{at}


A case of mass-forming breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) with onset a short time after explanation of the cosmetic prosthesis is reported. The cause of implant removal was carcinoma diagnosed in the ipsilateral breast. The rarity of an almost synchronous manifestation of BIA-ALCL and breast carcinoma and the diagnostic challenges of mass-forming BIA-ALCL in a previously operated breast substantiate this report. The clinical course, diagnostic workup and therapeutic considerations are presented and discussed in detail. This case shows that a diagnosis of BIA-ALCL must always be considered even without a prosthesis in place in patients with a long history of textured implants.

  • breast cancer
  • breast surgery
  • plastic and reconstructive surgery
  • surgical oncology
  • haematology (incl blood transfusion)

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  • Contributors MR is the consultant surgeon. She has initiated the presentation of the case report. She has written the manuscript with important information from the other authors involved. She is responsible for the surgical part of the manuscript. GC is the pathologist involved in the histological diagnostics for the patient. He is responsible for the histopathological aspect of the manuscript. GL is the oncologist/haematologist involved in the treatment of the patient. He is responsible for the description of the treatment of the patient. His department will oversee the follow up of the patients haematological disorder. AT is the radiologist involved in the radiological diagnostics of the patient. She has reviewed all the radiological examinations done on the patient. She is responsible for the radiological statements and considerations in the manuscript.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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