Article Text

Download PDFPDF
Neonatal thyrotoxicosis with maternal hypothyroidism
  1. Shruthi Ravindra and
  2. Sahana Shetty
  1. Department of Endocrinology, Manipal Academy of Higher Education (MAHE), Kasturba Medical College Manipal, Udupi, Karnataka, India
  1. Correspondence to Dr Sahana Shetty; sahanashetty0606{at}


Neonatal Graves’ is uncommon, but a potentially fatal condition caused by transplacental transfer of thyroid stimulating immunoglobulin (TSI). It is seen in 1%–5% of infants born to a mother with Graves’ disease. Here, we report a unique case of transient neonatal thyrotoxicosis with positive TSI in a premature neonate born to the mother with primary hypothyroidism. A short course of antithyroid drug treatment leads to significant clinical and biochemical improvement followed by complete recovery.

  • thyrotoxicosis
  • materno-fetal medicine
  • neonatal intensive care
  • immunology

Statistics from


  • Contributors SR wrote manuscript under supervision of SS. SS supported in collecting other review articles and management plans. Both SR and SS contributed to final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.