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Rare cause of deranged liver profile in pregnancy
  1. Paul Farrugia,
  2. Christopher Portelli and
  3. Malcolm Buhagiar
  1. Oncology, Mater Dei Hospital, Msida, Malta
  1. Correspondence to Dr Paul Farrugia; paul-mark.farrugia{at}


We present the case of a 33-year-old pregnant woman with an abnormal liver profile secondary to liver metastases from colon cancer. The patient presented in her third trimester with non-specific symptoms. Blood tests revealed a cholestatic liver picture, initially attributed to prurigo gravidarum. However, following a normal vaginal delivery, her symptoms persisted and the liver profile failed to return to baseline. This led to further investigations including a CT scan of the abdomen—revealing a transverse colonic tumour with extensive liver involvement. Biopsy of the liver confirmed an adenocarcinoma of colonic origin, and subsequently the patient underwent a right hemicolectomy followed by systemic chemotherapy.

  • Pregnancy
  • Liver disease
  • Colon cancer
  • Pancreas and biliary tract

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  • Contributors PF was the primary author. He was involved in obtaining patient consent, acquisition of images and blood test results, literature review, writing, editing and submitting this case report. MB was the main supervisor. He was the caring oncologist of the patient, and was involved in writing, editing, proofreading and literature review. CP was directly involved in writing, editing and proofreading.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.