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Isolated metastatic melanoma to the pancreas in the context of myeloproliferative neoplasm: a rare occurrence
  1. Jasper Johar1,
  2. Ashley Stueck2,
  3. Abhinaya Yeddala1 and
  4. Ali Kohansal3
  1. 1Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
  2. 2Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
  3. 3Division of Digestive Care and Endoscopy, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
  1. Correspondence to Dr Ali Kohansal; kohansal{at}


Isolated metastatic melanoma to the pancreas is a rare occurrence, representing less than 1 per cent of metastatic melanoma. This case describes the clinical presentation and course of illness of a patient who was diagnosed with a solitary metastasis to the pancreas 11 months after a clear margin resection of a pT1b, stage IB melanoma. Her melanoma metastasis was diagnosed on Endoscopic Ultrasound-Fine Needle Biopsy (EUS-FNB). This patient was found to have a concurrent myeloproliferative neoplasm (MPN) at the time of diagnosis. This case importantly highlights the course of a rare finding in isolated metastatic melanoma to the pancreas that may have been accelerated by the patient’s immunocompromised state with concurrent MPN. A high index of suspicion must be raised in patients with abdominal symptoms and melanoma history as the therapeutic window for these patients is quite narrow.

  • dermatology
  • endoscopy
  • pancreas and biliary tract
  • skin cancer
  • pancreatic cancer

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  • Presented at The abstract form of this case has been presented to the 2021 Annual Meeting of the American College of Gastroenterology as a poster.

  • Contributors Our contributing authors include JJ, AS, AY, and AK. JJ reviewed the relevant literature, compiled the patient history and diagnostic reports from the patient record, and consented the patient for the case study. AY was involved in doing a literature review of the subject, as well as editing the manuscript. AS is the consultant hepatopancreaticobiliary pathologist who reported the EUS biopsy results, captured the photomicrographs and edited the manuscript. AK is the consultant staff gastroenterologist who performed the EUS-FNA and supervised the preparation of this case report.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.