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Nephrotic syndrome with minimal change disease after the Pfizer-BioNTech COVID-19 vaccine: two cases
  1. James Leon Hartley1,
  2. Neil Bailey2,
  3. Asheesh Sharma3 and
  4. Howida Shawki4
  1. 1Nephrology, Royal Liverpool University Hospital, Liverpool, UK
  2. 2Nephrology, Warrington and Halton Teaching Hospitals NHS Foundation Trust, Warrington, UK
  3. 3Nephrology, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool, UK
  4. 4Histopathology, Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK
  1. Correspondence to Dr James Leon Hartley; james.hartley{at}


We present two cases of nephrotic syndrome with minimal change disease after the Pfizer-BioNTech COVID-19 vaccine. We discuss the initial presentation, investigation and management of these patients along with a discussion around the current evidence base for vaccine-induced nephrotic syndrome.

  • COVID-19
  • immunological products and vaccines
  • renal system
  • vaccination/immunisation
  • nephrotic syndrome

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  • Contributors JLH, as the main author of the article, composed the case series and compiled the case reports, and was responsible for investigations, management and follow-up. NB, as the second author, compiled literature review and references. AS, as the third author, oversaw preparation of the manuscript for publication and aided with literature review. HS provided histopathology slides and comments.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.