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Parathyroid carcinoma presenting with ventricular bigeminy in pregnancy
  1. Leher Gumber1,
  2. Karthikeyan Sivasankaran2 and
  3. Sardar Mohammad Shoaib Khan2
  1. 1Nottingham University Hospitals NHS Trust, Nottingham, UK
  2. 2Sherwood Forest Hospitals NHS Foundation Trust, Sutton-In-Ashfield, UK
  1. Correspondence to Dr Karthikeyan Sivasankaran; karthik.sankar1100{at}


Parathyroid carcinoma is very rare in pregnancy. Clinical features are similar to primary hyperparathyroidism. A 38-year-old pregnant woman had repeated hospital admissions for palpitations, headaches, dizziness and polydipsia. Blood investigations showed severe hypercalcaemia with raised parathyroid hormone and 24-hour ECG showed ventricular bigeminy and premature ventricular contractions. Neck ultrasound showed a lesion in the right thyroid lobe. Consequently, she underwent an en bloc resection of the right parathyroid and thyroid lobe at 23 weeks gestation. Histology results confirmed parathyroid cancer. This case highlights the complexities of identifying hypercalcaemia in pregnancy due to the overlapping features with common disorders of pregnancy. Early recognition and timely surgical management can prevent maternal and fetal complications. Also, the case demonstrates the value of interprofessional collaboration between different specialities in providing quality care and improving outcomes. An abridged version of this case was presented at European Congress of Endocrinology 2021.

  • calcium and bone
  • endocrinology
  • pregnancy
  • endocrine cancer

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  • Contributors SMSK identified and consented the patient. KS analysed the data and LG drafted the manuscript. All authors reviewed and approved the final manuscript prior to submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.