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Recurrent thrombosis as a clinical presentation of Whipple disease
  1. María Terrones-Peinador1,
  2. Simeón Eremiev-Eremiev2,
  3. Carlos Pigrau-Serrallach2 and
  4. Roser Solans-Laque1
  1. 1Internal Medicine Department, Vall d'Hebron University Hospital, Barcelona, Catalunya, Spain
  2. 2Infectious Diseases Department, Vall d'Hebron University Hospital, Barcelona, Catalunya, Spain
  1. Correspondence to Dr María Terrones-Peinador; mterrones{at}


Whipple’s disease (WD) is a rare infectious disease with a wide clinical spectrum. Associated thrombotic manifestations are not well described in WD, only related to ‘stroke-like syndrome’. We present a case of a 39-year-old man with a 1-year history of self-limited episodes of fever, associated with generalised adenopathies and recurrent superficial and deep venous thrombosis events, which have resorted four times despite the anticoagulant treatment. Finally, the patient is diagnosed with WD. Following treatment the patient improved in his general condition, and no more episodes of fever neither thrombosis appeared during a follow-up of more than 3 years.

  • bone and joint infections
  • haematology (incl blood transfusion)
  • infection (gastroenterology)

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  • Contributors MT-P and SE-E reviewed data and wrote the manuscript. CP-S and RS-L reviewed and edited the manuscript. All authors have reviewed and approved the final version of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.