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Inferior mesenteric vein thrombosis in the setting of testosterone therapy
  1. Ngoda Manongi,
  2. Kory Byrns,
  3. Malvina Fulman and
  4. Amir Jaffer
  1. Internal Medicine, NewYork-Presbyterian Queens, Flushing, New York, USA
  1. Correspondence to Dr Ngoda Manongi; nmanongi{at}


Inferior mesenteric vein thrombosis (IMVT) is a rare and potentially lethal complication that can progress to mesenteric ischaemia if left untreated. We report a case of a man in his 70s with a history of polycythaemia vera (PV) with a known negative Janus kinase-2 mutation (JAK2V617) who was started on testosterone therapy 2 months before presenting with left lower quadrant abdominal and flank pain. Evaluation revealed thrombocytosis and IMVT on CT scan. A non-operative approach was deferred for anticoagulation therapy. Within 24 hours, the patient demonstrated significant clinical improvement, and he subsequently made a full recovery. The patient underwent 6 months of anticoagulation therapy with Apixaban. This case documents the first case of IMVT in the setting of PV and testosterone therapy in the literature.

  • Contraindications and precautions
  • Haematology (drugs and medicines)
  • Medical education
  • Medical management

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  • Contributors Description of author roles in manuscript creation. Conceptualisation: NM and MF. Data curation: NM and MF. Validation: NM, MF and AJ. Visualisation: NM, AJ and KB. Writing—original draft: NM and MF. Writing—review and editing: NM, KB and AJ. The article guarantor: NM.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.