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Myelin oligodendrocyte glycoprotein (MOG) antibody-associated longitudinally extensive transverse myelitis (LETM) and primary Sjogren syndrome: a rare association
  1. Debananda Sahoo,
  2. Anil Dash,
  3. Anupam Dey and
  4. Sujata Devi
  1. Department of General Medicine, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India
  1. Correspondence to Dr Debananda Sahoo; drdebanandasahoo{at}


Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a recent addition to the field of central nervous system inflammatory disorders. It can have a wide range of presentations, including optic neuritis, transverse myelitis, acute disseminated encephalomyelitis or any combination of these. The aquaporin-4-positive neuromyelitis optica (NMO) is a close differential owing to the similar clinical presentation. There is a proven association between NMO and autoimmunity, whereas such an association is yet to be established in the case of MOGAD. Here we describe the case of a woman in her 30s presenting with sudden-onset quadriparesis with sensory and autonomic involvement who was diagnosed with MOGAD (cervicothoracic longitudinally extensive transverse myelitis) and found to have primary Sjogren syndrome on further workup. This association between MOGAD and autoimmunity should be kept in mind, as diagnosis of the former should alert the physician to the possibility of the latter’s existence and the need to initiate an appropriate workup.

  • Immunology
  • Connective tissue disease
  • Sjogren's syndrome
  • Neurology (drugs and medicines)
  • Spinal cord

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  • Contributors All the authors have contributed to the article. DS has contributed in the form of literature search, manuscript preparation and reporting. ADash has contributed in the form of literature search, data acquisition, analysis and interpretation of data. ADey has contributed in the form of conception and design of the article. SD has contributed in the form of conceiving the idea and planning for the article writing.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.