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Case Reports: Rare disease
Surgical management of a congenital genital tract abnormality in a patient with Lynch syndrome
  1. Eniola Olayato-Aribo,
  2. Nicholas Wood,
  3. Divya Nagaiah and
  4. Thomas Underwood
  1. Gynaecology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK
  1. Correspondence to Dr Eniola Olayato-Aribo; eniolaaribo{at}doctors.org.uk

Abstract

Lynch syndrome (LS), also known as hereditary non-polyposis colorectal cancer, is an inherited cancer syndrome which increases the risk of developing colorectal cancer and endometrial cancer. Individuals with LS have an increased risk of cancers of the ovary, urinary tract, stomach, small intestine, pancreas, biliary tract, brain and skin. Cancer risk reduction is recommended through chemoprevention (aspirin), surveillance (colonoscopy, assessment of the endometrium and ovaries via USS, aspiration biopsy and tumour marker monitoring; CA125) or risk reduction surgery, that is, total hysterectomy and bilateral salpingo-oophorectomy.

This is a case of a nulliparous woman in her early 30s with LS and a congenital genital tract malformation. She had a unicornuate (left) uterus and a vestigial (right) uterine horn. There was an inability to obtain a conclusive set of endometrial biopsies in this patient due to the nature of the patient’s congenital uterine abnormality. In this case, surgery was recommended to excise the vestigial horn and fallopian tube in order to optimise surveillance and fertility.

  • Reproductive medicine
  • Obstetrics and gynaecology

http://dx.doi.org/10.1136/bcr-2022-249833

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    Footnotes

    • Contributors EO-A was the main author involved in planning, data collection, writing and submission of the manuscript. NW was the primary clinician in this case involved in the conception, planning and critical revision of the manuscript. DN was involved in patient care and revising the manuscript. TU was involved in data collection. All authors read and approved the final version of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.