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Case Reports: Rare disease
Hyperammonaemia syndrome in disseminated Ureaplasma parvum infection
  1. Nadiya Brell1,2,
  2. Kristen Overton1,2,
  3. Milton J Micallef2 and
  4. Siobhan Hurley2
  1. 1University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia
  2. 2Infectious Diseases, Prince of Wales Hospital and Community Health Services, Randwick, New South Wales, Australia
  1. Correspondence to Dr Nadiya Brell; nadiya.brell{at}health.nsw.gov.au

Abstract

Hyperammonaemia syndrome secondary to Ureaplasma spp. infection is well documented in the post-lung transplant population. We report a case of a man in his fifties with hyperammonaemia syndrome secondary to disseminated Ureaplasma parvum infection. This occurred in the context of immunosuppression for chronic graft versus host disease and six years following an allogeneic stem cell transplant for diffuse large B-cell lymphoma. Following treatment of U. parvum septic arthritis with ciprofloxacin and doxycycline, the patient experienced a full neurological recovery, and continues on suppressive doxycycline therapy with no recurrence of symptoms to date.

  • Malignant disease and immunosuppression
  • Bone and joint infections
  • Infectious diseases

https://doi.org/10.1136/bcr-2022-250852

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    Footnotes

    • Contributors NB, KO, MJM and SH were involved in the patient’s care and contributed to writing of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.