You are here

Article Text

Article menu
Download PDFPDF
Case Reports: Reminder of important clinical lesson
Renal injury in scleromyxoedema due to monoclonal gammopathy associated C3 glomerulonephritis
  1. Stephanie Kao1,
  2. Sonia D Silinsky Krupnikova2,
  3. Maha AlMackenzie3 and
  4. Gelareh Atefi4
  1. 1Department of Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA
  2. 2Arthritis and Rheumatism Associates, PC, Wheaton, Maryland, USA
  3. 3Division of Rheumatology, Department of Medicine, Medical Cities of the Ministry of the Interior, Riyadh, Saudi Arabia
  4. 4Immunology, AstraZeneca, Wilmington, Delaware, USA
  1. Correspondence to Dr Stephanie Kao; skao{at}mfa.gwu.edu

Abstract

Scleromyxoedema is a rare mucinosis that primarily affects the skin. It is associated with monoclonal gammopathy and has many extracutaneous manifestations, however, renal involvement is rare. We report the case of a woman with monoclonal gammopathy and scleromyxoedema presenting with progressive exertional dyspnoea and acute renal failure. Workup of her renal failure revealed monoclonal gammopathy associated C3 glomerulonephritis. She was treated with intravenous steroids and discharged with plans to pursue annual monoclonal gammopathy laboratory monitoring. Given the rarity of renal scleromyxoedema, careful investigation of extracutaneous manifestations and comorbidities is critical to discern the primary pathological process in patients with scleromyxoedema who develop renal insufficiency.

  • Rheumatology
  • Acute renal failure

https://doi.org/10.1136/bcr-2022-250296

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Twitter @almackenziemaha

    • Contributors SK: design and conceptualisation of the case report, involved in clinical care, acquisition of data, analysis and interpretation of data, drafting of manuscript. SDSK: design and conceptualisation of the case report, involved in clinical care, acquisition of data, analysis and interpretation of data, drafting of manuscript. MA: involved in clinical care, acquisition and interpretation of data, revision of manuscript for intellectual content. GA: involved in clinical care, interpretation of data, revision of manuscript for intellectual content.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.