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Atypical case of retinopathy of prematurity with candle wax-like preretinal deposits and its surprising response to intravitreal antivascular endothelial growth factor
  1. Miloni Suketu Shah1,
  2. Srikanta Kumar Padhy2,
  3. Suman Sahu1 and
  4. Tapas Ranjan Padhi1
  1. 1Retina, LV Prasad Eye Institute Bhubaneswar Campus, Bhubneshwar, Odisha, India
  2. 2Ophthalmology, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, Odisha, India
  1. Correspondence to Dr Tapas Ranjan Padhi; tapas{at}


Presented here is a case of hybrid retinopathy of prematurity (ROP) with features of both aggressive posterior ROP and ridge-like staged ROP with extensive candle wax-like preretinal deposits plastered on the surface of the retina from optic disc to vascular–avascular junction at a postmenstrual age (PMA) of 34 weeks. The baby was too sick for laser photocoagulation and so underwent intravitreal bevacizumab at half adult doses in both eyes. The deposits melted dramatically within 1–2 weeks of antivascular endothelial growth factor injection without any signs of recurrence till the last visit at 58 weeks of PMA.

  • retina
  • neonatal health

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  • Contributors MSS: manuscript writing. SKP: acquisition of data and manuscript revision. SS: acquisition of data. TRP: revision of manuscript, conception of idea.

  • Funding Hyderabad Eye Research Foundation (LEC-BHR-R-06-21-677).

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.