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Essential thrombocythemia with portal vein thrombosis and splenic infarction successfully treated with platelet apheresis
  1. Ami Mehul Mehta1,
  2. Shubha Seshadri1,
  3. Seemitr Verma2 and
  4. Sharath P Madhyastha1
  1. 1Internal Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
  2. 2Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
  1. Correspondence to Dr Sharath P Madhyastha; dr.sharathymc{at}


A 63-year-old diabetic woman presented to the outpatient clinic with a 1-week history of abdominal pain. On complete evaluation, she was diagnosed to have essential thrombocythemia. Abdominal imaging revealed portal vein thrombosis with a large splenic infarct. The patient was started on anticoagulant, antiplatelet and cytoreductive therapy. In view of persistent high platelet count, plasma apheresis was done, following which the patient’s platelet counts were reduced. Essential thrombocythemia has a high rate of complications, resulting in significant morbidity and mortality. Few cases of this disease and its treatment have been described in the literature, especially pertaining to the Indian scenario. Further studies are needed to establish a multidisciplinary algorithm for its diagnosis and to elucidate the guidelines for the successful treatment of the condition.

  • haematology (drugs and medicines)
  • haematology (incl blood transfusion)
  • malignant and benign haematology
  • medical management
  • portal vein

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  • Contributors AMM wrote the draft of the manuscript. SPM revised the manuscript critically for important intellectual content. SS involved in patient management. SV involved in the histopathological diagnosis and provided the bone marrow biopsy photomicrograph. All the authors contributed to the literature review and approved the final manuscript for submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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