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Topical medication as an initial therapeutic option for protruding and non-protruding condylomata acuminata of the distal urethra
  1. Tomislav Mestrovic1,2,
  2. Mario Sviben3,4,
  3. Sanja Zember5 and
  4. Domagoj Drenjancevic6,7
  1. 1Clinical Microbiology and Parasitology Unit, Dr. Zora Profozic Polyclinic, Zagreb, Croatia
  2. 2University Centre Varazdin, University North, Varazdin, Croatia
  3. 3Department of Medical Microbiology, School of Medicine, University of Zagreb, Zagreb, Croatia
  4. 4Microbiology Service, Croatian National Institute of Public Health, Zagreb, Croatia
  5. 5Department for Urogenital Infections, University Hospital for Infectious Diseases 'Dr. Fran Mihaljević', Zagreb, Croatia
  6. 6Clinical Microbiology Department, University Hospital Centre Osijek, Osijek, Croatia
  7. 7Department of Microbiology and Parasitology, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
  1. Correspondence to Professor Mario Sviben; mario.sviben{at}


Genital warts (also known as condylomata acuminata) caused by the human papillomavirus (HPV) represent one of the most common sexually transmitted infections. Although they are usually found in the outer genital region, a small proportion of men can present with (often unrecognised) intraurethral warts, generally limited to the distal urethra and urethral meatus. This poses a treatment challenge not adequately addressed by the current guidelines. Here, we present two cases of low-risk HPV-positive patients with protruding and non-protruding condylomata acuminata of the distal urethra, which were treated successfully by using two different topical regimens (ie, a combination of policresulen and imiquimod for one patient and 5-fluorouracil monotherapy for the other). Although this type of management results in lower rates of tissue destruction and complications and may be given preference as an initial therapeutic option, additional prospective comparative clinical studies are needed to elucidate its potential in similar cases.

  • human papilloma virus
  • urology
  • sexual health
  • dermatology

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  • Contributors TM—design, draft, edit and review; MS—draft, edit and review; SZ—edit and review; DD—edit and review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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