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Subcutaneous panniculitis-like T cell lymphoma arising in association with chronic lymphocytic leukaemia
  1. Lakshmi Shree Kulumani Mahadevan and
  2. Metin Ozdemirli
  1. Department of Anatomic and Clinical Pathology, Georgetown University Medical Center, Washington, DC, USA
  1. Correspondence to Dr Metin Ozdemirli; MO7{at}gunet.georgetown.edu

Abstract

Subcutaneous panniculitis-like T cell lymphoma (SPTCL) is a rare cutaneous T cell malignancy of cytotoxic T cell origin. It is frequently associated with autoimmune diseases. It is known to preferentially involve subcutaneous adipose tissue and histologically resembles lupus panniculitis. The aetiology and risk factors of SPTCL are unclear and there are limited studies available since this entity was initially described in 2001. There are even fewer case reports describing the association between SPTCL and chronic lymphocytic leukemia (CLL). In this article, we present a case of SPTCL arising during treatment for CLL. We conducted an extensive review of literature to delve into the possible risk factors for SPTCL development in association with CLL, including pre-existing haematological malignancies, autoimmune conditions, immunomodulation and immunosuppressive chemotherapy.

  • pathology
  • haematology (incl blood transfusion)
  • haematology (drugs and medicines)

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Footnotes

  • Contributors Both authors, LSKM and MO, equally contributed to the conception and design, acquisition of data, drafting and revising the intellectual content, final approval of the version to be published and agree to be accountable for all questions regarding accuracy or integrity of the article.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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