Article Text

Download PDFPDF

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE): a rare self-healing oral mucosal lesion
Free
  1. Abhishek Banerjee1,
  2. Satya Ranjan Misra2,
  3. Vivek Kumar1 and
  4. Neeta Mohanty3
  1. 1Oral & Maxillofacial Pathology, Awadh Dental College and Hospital, Jamshedpur, Jharkhand, India
  2. 2Oral Medicine & Maxillofacial Radiology, Institute of Dental Sciences, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, India
  3. 3Oral & Maxillofacial Pathology & Microbiology, Institute of Dental Sciences, Siksha O Anusandhan Deemed to be University, Bhubaneswar, Odisha, India
  1. Correspondence to Professor Neeta Mohanty; neetamohanty{at}soa.ac.in

Statistics from Altmetric.com

Description

Oral ulceration is a common report encountered by the oral physician, and a solitary ulcer of long duration especially when it is asymptomatic and occurs in middle aged and elderly patients is always under suspicion for oral squamous cell carcinoma.1 Chronic trauma of the oral mucosa (CTOM) due to repeated mechanical irritation from an intraoral injury agent has been debated as an oral potentially malignant disorder contributing to oral carcinogenesis and needs to be evaluated ruling out other associated contributing factors like tissue abuse habits and oral hygiene.2 Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an uncommon self-limiting oral mucosal lesion. It presents as a single ulcer which may be asymptomatic or associated with pain with the dorsum or the tip of the tongue being the most common site. The importance of this rare lesion lies in the fact that it is often misdiagnosed as oral carcinoma or specific infections like tuberculosis, primary syphilis or Epstein-Barr virus ulcer. Biopsy is mandatory and exhibits typical histological findings diffuse polymorphic inflammatory infiltrate, predominately consisting of histiocytes, activated and predominantly T-lymphocytes, and of eosinophils with the lesion extending deep into the submucosa, deeper muscle fibres and even the salivary glands.3 Eosinophils are known to regulate local inflammatory and immune responses; hence, their presence is associated with inflammation and infection and their abundance in this lesion indicates an associated inflammatory component. The aetiopathogenesis of TUGSE is debatable but a localised traumatic cause is a significant predisposing factor as seen in this case, though it may be absent in half of the cases.4 These lesions show a male gender predilection with an age range of 41–60 years. The lesions generally heal following biopsy. TUGSE is entirely a histologic entity and is incidentally diagnosed when lesions associated with CTOM are biopsied suspecting malignancy.

A 35-year-old woman presented with an ulcer in the right buccal mucosa which had been present for about 7 months. History revealed the ulcer had been associated with pain and did not increase in size over time. The patients’ medical history was unremarkable. On clinical examination, a single irregular ulcer measuring 1 cm×1.5 cm in size was seen on the right buccal mucosa in relation to carious maxillary molars 17, 16. The floor of the ulcer was erythematous and the borders irregular and whitish in colour. The indentation of the tooth cusp of maxillary molar was apparent on the ulcer surface (figure 1). On palpation, the base appeared indurated and was slightly tender. As it was a long-standing solitary ulcer, chronic traumatic ulcer, tuberculous ulcer and malignant ulcer were considered in the clinical differential diagnosis.

Figure 1

A solitary, irregular ulcer on the right buccal mucosa in relation to carious maxillary molars having an erythematous floor and irregular hyperkeratotic white borders with indentation of the tooth cusp of maxillary molar on the ulcer surface.

Routine haematologic investigations and panoramic radiography were unremarkable. As the patient was unwilling for tooth extraction, the sharp edges of the maxillary molars on the right side were smoothened to relieve the pain. An excisional biopsy was performed under local anaesthesia and the tissue was sent for histopathological evaluation owing to the duration of this long-standing non-healing lesion. The H&E-stained sections revealed that the lesion was infiltrative and involving the striated muscle with a para-keratinised hyperplastic epithelium (figure 2A,B). The stroma was abundantly infiltrated with chronic inflammatory infiltrate-like lymphocytes, histiocytes and pool of eosinophils at focal areas (figure 2C,D). A granulomatous pattern seen in the stroma with focal areas of degeneration without any cell atypia. The histopathologic features indicated TUGSE and the patient was kept on regular follow-up and the lesion almost completely healed in 3 months (figure 3).

Figure 2

H&E-stained section showing (A) infiltrative lesion with dense granulomatous reaction in the stroma (original magnification 5×) and (B) infiltration of the chronic inflammation at the level of deeper connective tissue extending into the musculature (original magnification 10×). At higher magnification, presence of (C) tissue macrophages along with budding vascular channels and lymphocytes and (D) pool of eosinophils along with other components of chronic inflammation are seen (original magnification 40×).

Figure 3

Healed ulcer on the right buccal mucosa indicating the self-limiting nature of the lesion.

Learning points

  • Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare ulcerative oral mucosal lesion.

  • TUGSE often mimics infectious diseases or malignancy, thereby making biopsy mandatory for diagnosis along with a meticulous clinical examination.

  • It does not mandate any specific treatment except topical analgesic–anaesthetic gel may be applied for symptomatic relief.

Ethics statements

References

Supplementary materials

Related Data

Footnotes

  • Contributors SRM examined the patient and performed the biopsy. AB and VK performed the histopathologic evaluation. NM prepared the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.