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Iatrogenic biloma: a rare and delayed complication of a life-saving transarterial hepatic embolisation
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  1. Amit R Hudgi1,
  2. Haoran Peng2,
  3. Subbaramia Sridhar2 and
  4. John Erikson Yap2
  1. 1Internal Medicine, Augusta University Medical College of Georgia, Augusta, Georgia, USA
  2. 2Division of Gastroenterology and Hepatology, Augusta University Medical College of Georgia, Augusta, Georgia, USA
  1. Correspondence to Dr Amit R Hudgi; amithudgi{at}gmail.com

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Description

A 29-year-old African-American man was admitted after a motor vehicle accident (MVA). He was an unrestrained driver, ejected from the vehicle which struck a stationary pole. He had significant blunt trauma to face, chest, abdomen and left lower extremity. CT angiography (CTA) of the abdomen showed a grade-4 liver injury with complex stellate laceration disrupting segments 4A, 4B, 5, 8 and the caudate lobe. There were a few foci of possible venous bleed but no obvious active arterial bleeding was noted. The patient underwent hepatic angiogram, which showed a large laceration in the segment 8. A 0.4 cm segment 4 pseudoaneurysm and a 0.6 cm segment 8 pseudoaneurysm were noted during the procedure with possible developing tract connection between the two segments. Selective gel foam embolisation of segment 8 hepatic arterial branch was performed successfully. A repeat CTA performed 1-day post-transarterial hepatic artery embolisation confirmed no active bleeding. On postoperative day 9, the patient developed persistent low-grade fever of 37.8°C. The laboratory values were significant for elevated white cell count of 14 x109/L, total bilirubin of 1.6 mg/dL, aspartate transaminase of 126 U/L, alanine transaminase of 126 U/L and alkaline phosphatase of 164 U/L. A repeat CT scan of the abdomen was performed which revealed a new 3.1×2 cm cystic region of fluid density identified between segments 2 and 4 (figure 1).

Figure 1

CT scan of the abdomen showing a 20.5×31.3 mm size biloma identified as a complication of the transarterial embolisation procedure.

This localised collection was identified as a biloma which is a rare complication after transarterial embolisation. He was placed on empiric antibiotics of ceftriaxone and metronidazole, later underwent endoscopic ultrasound-guided drainage as well as endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy and temporary plastic bile duct stent placement. A total of 5 mL bilious fluid from the anechoic rounded area with clear-cut border between the hepatic segment 4 and 2 as noted on endoscopic ultrasound (EUS) (figure 2) was successfully aspirated. The aspirated biliary fluid showed no growth of organisms on culture. Occlusion cholangiogram during the ERCP procedure showed small calibre intrahepatic biliary system with no obvious extravasation of contrast. His symptoms resolved and laboratory values normalised over the following days.

Figure 2

Fine-needle aspiration of the biloma (3.1×2 cm, annotated above) under the guidance of the endoscopic ultrasound (EUS).

A biloma is a localised collection of bile within the abdomen usually as a result of bile duct injury. They can be differentiated based on their location to be either intrahepatic or parahepatic. Bilomas are mostly asymptomatic but may present with abdominal pain, fever, jaundice or rarely peritonitis.1They are identified as homogeneous collection on a CT or MRI scan. It is one of the uncommon complications of transarterial chemoembolisation (TACE) usually while treating hepatocellular carcinoma.1 2 This is one of the few cases reported in a patient after transarterial embolisation for traumatic liver injury.3 The risk factors that contribute to this rare complication includes underlying liver pathology such as cirrhosis of the liver, number of TACE procedures, prior liver resection, dilated common bile duct and use of polyvinyl alcohol for the procedure.1 The mechanism behind this phenomenon is poised secondary to ischaemia of intrahepatic bile ducts which obtain their blood supply from the hepatic artery.3 In our case, due to the complex hepatic laceration and pseudoaneurysms development in segment 4 and 8 of the liver, there was a concern of a developing tract connection between the two segments. It is likely that some of the gel foam used to embolised the segment 8 vessel strayed and affected segment 4 as well. An important common differential for biloma formation is direct trauma to the bile duct especially in patients with complex lacerations in the liver due to MVA. In this particular case, the biloma did not appear during initial abdominal imaging and even after repeat imaging immediately after transarterial hepatic embolisation. The biloma was identified only after 9 days postprocedure and this is due to increasing bilirubin levels and low-grade fever. A delayed biloma due to bile duct injury was entertained but an occlusion cholangiogram during the ERCP showed intact and patent intrahepatic biliary system. Most of the cases can be treated conservatively. However, any signs of infection or enlarging size of the biloma should prompt endoscopic or percutaneous drainage.

Patient’s perspective

This was an eye-opening experience for me. I am emotionally shocked after this incident. I am thankful for the minimally invasive procedure performed without the need for any open surgery. I am more than willing to share my experience with the medical community and kindly communicate with me after acceptance of the article.

Learning points

  • Intrahepatic arterial embolisation could be a life-saving modality for various critical and life-threatening hepatic lacerations and bleeding, it is important to recognise that biloma can be one of the serious complications.

  • A high clinical suspicion to obtain imaging is necessary when a patient postembolisation presents with symptoms and laboratory parameters concerning for a biloma.

  • Most of the cases can be treated conservatively. However, any signs of infection or enlarging size of the biloma should prompt endoscopic or per-cutaneous drainage.

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Footnotes

  • Contributors Conception and design, acquisition of data or analysis, and interpretation of data: ARH and JEY. Drafting the article or revising it critically for important intellectual content: ARH, JEY and HP. Final approval of the version published: SS and JEY. Agreement to be accountable for the article and to ensure that all questions regarding the accuracy or integrity of the article are investigated and resolved: JEY.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.