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Case report
Remitting seronegative symmetrical synovitis with pitting oedema following BNT162b2 mRNA COVID-19 vaccination
  1. Konstantinos Parperis1,2 and
  2. Maria Constantinou2
  1. 1The University of Arizona College of Medicine Phoenix, Phoenix, Arizona, USA
  2. 2University of Cyprus Medical School, Nicosia, Nicosia, Cyprus
  1. Correspondence to Dr Konstantinos Parperis; konstantinos.parperis{at}gmail.com

Abstract

Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) is a rare inflammatory condition that occurs in older adults. Here, we report a case of an 80-year-old man with no history of rheumatic disease who presented with acute onset of bilateral hand pain, pitting oedema and synovitis after the second dose of the BNT162b2 mRNA C0VID-19 vaccine. Laboratory workup revealed elevated inflammatory markers and negative autoantibodies. Significant improvement was noted with prednisolone. This is the first reported case of RS3PE in an elderly patient with no previous rheumatic disease following mRNA COVID-19 vaccination.

  • musculoskeletal syndromes
  • COVID-19

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https://bmj.com/coronavirus/usage

https://doi.org/10.1136/bcr-2021-244479

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    Footnotes

    • Contributors Both authors, KP and MC had substantial contribution to the conception or design of the work; the acquisition, analysis or interpretation of data for the work; and drafted the work and revised it critically for important intellectual content; and final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.