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Management of late events after conventional radical prostate radiotherapy: against the odds of secondary tumours and recurrence of prostate cancer
  1. Rodriguez-Perez AR1,
  2. Montero-Feijoo M2,
  3. Blanco-de-Córdoba LA3 and
  4. Luna-Tirado J2
  1. 1Medical Oncology, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Madrid, Spain
  2. 2Radiation Oncology, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain
  3. 3Pathology Department, Fundación Jiménez Díaz, Madrid, Spain
  1. Correspondence to Dr Rodriguez-Perez AR; angel.r.p1394{at}


We present two 85-year-old men, with a similar history of prostate cancer treated more than 10 years ago with radiotherapy, who were in remission, but sought medical care at a time, due to alarm sign and symptoms. Case 2 resulted in a locally advanced secondary radiation-induced sarcoma of the penile base. Case 1 suffered from a round, 2 cm soft-tissue lesion with spiculated borders at the ureterovesical junction responsible for ipsilateral iliac vein compression and urinary obstruction without proven biochemical prostate cancer relapse, raising concerns about recurrence or secondary tumour. Both patients followed an oncological geriatric assessment and were ‘vulnerable’ at their presentation. Hence, we describe the effort to perform medical care adequacy regarding patient’s frailty and the anatomic locations within the prior radiation field. In case 2, we got a pathological diagnose and followed sequential multimodal treatments without success. But in case 1, minimal intervention resulted in improvement.

  • prostate cancer
  • radiotherapy
  • urological cancer
  • long term care

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  • Contributors ARP and MMF contributed equally to this paper. LABdC contributed with pathology examinations and review. JL contributed with technical expertise and revision of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.