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Extraosseous odontogenic fibroma with a clear cells component: a 5-year follow-up
  1. Estefanía Retama-Carranza1,
  2. Miguel Padilla-Rosas1,
  3. José Sergio Zepeda-Nuño2 and
  4. Mario Nava-Villalba2
  1. 1Master's Program in Oral Pathology and Medicine, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, México
  2. 2Department of Microbiology & Pathology, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, México
  1. Correspondence to Dr Mario Nava-Villalba; mario.nava{at}


The extraosseous/peripheral odontogenic fibroma (E/POF) is a benign mesenchymal odontogenic tumour found on the gingival surface with clinical characteristics identical to those of reactive lesions. A histopathological analysis is the only method for determining the difference between reactive lesions and these neoplastic lesions, whose recurrence potential varies between 38.9% and 50%, highlighting the importance of correct diagnosis. The following report describes an E/POF case with a clear cells component, as well as a long-term follow-up treatment, which we emphasise due to its potential for recurrence.

  • dentistry and oral medicine
  • pathology

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  • Contributors JSZ-N was the specialist in charge of reception and handled patient. MP-R was the specialist in charge of surgical procedures. ER-C, MP-R and MN-V performed histological and immunohistochemical examinations. ER-C and MN-V were in charge of obtaining, consolidating and analysis of the literature. JSZ-N, MP-R, ER-C and MN-V contributed to scientific discussions and critically revised the manuscript. ER-C and MN-V made the follow-up of the case. ER-C and MN-V provided the concept design and scientific direction and contributed to the drafting and edition of the manuscript. All authors read and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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