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Hypercalcaemia due to ovarian small cell carcinoma of the hypercalcaemic type
  1. Annalisa Montebello and
  2. Mark Gruppetta
  1. Department of Diabetes and Endocrinology, Mater Dei Hospital, L-Imsida, Malta
  1. Correspondence to Dr Annalisa Montebello; a.montebello{at}


A 37-year-old woman presented with a few days’ history of lower abdominal pain and an incidental finding of hypercalcaemia. A thorough workup ensued, and the cause was found to be an exceptionally rare ovarian tumour—ovarian small cell carcinoma of the hypercalcaemic type. Acute treatment of hypercalcaemia consisted of aggressive intravenous fluids and bisphosphonates. She underwent surgery to remove the tumour and is currently receiving systemic platinum/etoposide chemotherapy combination to be followed by pelvic radiotherapy. This case highlights the wide range of differential diagnosis for hypercalcaemia and the importance of a stepwise and thorough approach during investigations. We discuss the pathophysiology of malignancy-related hypercalcaemia, focusing especially on parathyroid hormone-related peptide-associated hypercalcaemia.

  • cancer intervention
  • endocrine system
  • metabolic disorders

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  • Contributors AM wrote up the case with constant guidance and reviews by MG.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer-reviewed.