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McCune-Albright syndrome onset with vaginal bleeding
  1. Ngo Van Doan1,
  2. Nguyen Minh Duc2,
  3. Vuong Kim Ngan1 and
  4. Nguyen Van Anh1
  1. 1Department of Radiology, Vinmec Healthcare System, Hanoi, Viet Nam
  2. 2Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh, Viet Nam
  1. Correspondence to Dr Nguyen Minh Duc; bsnguyenminhduc{at}


McCune-Albright syndrome (MAS), a rare genetic disorder, affects multiple organs and classically presents with the triad of polyostotic fibrous dysplasia (FD), skin hyperpigmentation (café-au-lait spots) and precocious puberty. Diagnosis occurs when patients manifest at least two of these three symptoms. We describe a 4-year-old girl who was admitted to our hospital due to recurrent vaginal bleeding, initially diagnosed as precocious puberty. On brain MRI, abnormalities in the maxillary and occipital bones were compatible with FD. Clinical examination after craniofacial bone lesions and clinical signs indicated MAS revealed abnormally pigmented macules on the neck and back, which were initially overlooked. No abnormal hormone tests were observed. Precocious puberty is the most common MAS-associated symptom that results in the admission to the hospital, whereas the clinical manifestation of FD in the first years of life is usually equivocal and probably has not been discovered by parents. Thus, comprehensive medical examinations are necessary to obtain a prompt and proper diagnosis.

  • radiology
  • radiology (diagnostics)
  • immunology
  • endocrinology

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  • NVD and NMD are joint first authors.

  • NVD and NMD contributed equally.

  • Contributors NVD and NMD contributed equally to this article as cofirst authors. NVD and NMD were responsible for writing and drafting the manuscript. NMD and VKN were responsible for reviewing, guiding, and editing the final draft. VKN and NVA were responsible for interpreting X-ray and MRI.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.