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Rapid onset vancomycin-induced thrombocytopenia confirmed by vancomycin antibody test
  1. Thakul Rattanasuwan1,
  2. Yael Marks1,
  3. Jess Delaune2 and
  4. Adonice P Khoury1
  1. 1College of Pharmacy, University of Florida, Gainesville, Florida, USA
  2. 2Department of Medicine, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Adonice P Khoury; akhoury{at}


We report a case of vancomycin-induced thrombocytopenia (VIT) with rapid onset after re-exposure to vancomycin. A 58-year-old man with cellulitis was initiated on vancomycin. Approximately 1 hour into the vancomycin infusion, the patient developed an infusion-related reaction. Vancomycin infusion was stopped. A complete blood count obtained 4 hours after discontinuation of the vancomycin infusion revealed a platelet count of 31 ×10­9/L. Investigations ruled out likely causes of thrombocytopenia. VIT was diagnosed based on clinical symptoms and confirmed with drug-dependent platelet antibody testing. Without complications, platelet counts recovered within 7 days after discontinuation of vancomycin. No correlation between vancomycin level and VIT was observed.

  • haematology (drugs and medicines)
  • infections

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  • Contributors JD, APK, TR and YM contributed to the drafting of the manuscript. All authors approved of the final draft for submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer-reviewed.