Article Text

Download PDFPDF
Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection
  1. Kevin Y Wang1,
  2. Pratik Shah1,
  3. Dennis T Roarke2 and
  4. Shams A Shakil3
  1. 1Department of Internal Medicine, NSLIJ Health System, New Hyde Park, New York, USA
  2. 2Department of Internal Medicine, Northwell Health, New Hyde Park, New York, USA
  3. 3Department of Hematology Oncology, Northwell Health, New Hyde Park, New York, USA
  1. Correspondence to Dr Kevin Y Wang; Kevwangyu{at}


A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports.

  • COVID-19
  • Haematology (drugs and medicines)

This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors KW wrote the initial draft and edited draft. PS assisted in editing the draft and contributing ideas. DTR assisted in editing the draft and contributing ideas. SAS assisted in editing the draft and contributing ideas.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer-reviewed.